A woman awakes in the morning to find that someone has picked her apartment's supposedly impregnable door lock and rearranged personal items, even sitting beside her while she slept. The intrusion, the police learn, is a message to the entire city of carnage to come. Lincoln Rhyme and Amelia Sachs are brought in to investigate and soon learn that the sociopathic intruder, who calls himself 'the Locksmith,' can break through any lock or security system...

"The Locard Institute is a state-of-the-art forensic research center where experts from around the world come together to confront and solve the world's most challenging and perplexing crimes. When Dr. Ellie Carr arrives for her first day as an instructor at the prestigious facility, the buildings glimmer amid the brilliant fall foliage on the shores of the Chesapeake Bay. But within hours a colleague, Dr. Barbara Wright, is found dead on the floor...